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Clinical trials of the safety and effectiveness of Melanotan are ongoing, but in 2008 the European Medicines Agency approved a blend of the peptide called Scenesse to be marketed for limited prescription-only use by those with specific skin conditions throughout the European Union

Safe alternatives include gradual dietary modification following the NHS Eatwell Guide, regular physical activity (150 minutes weekly of moderate-intensity exercise), and NHS weight management programmes

A small randomized study that compared acetate-free biofiltration and low-flux HD in ESA-treated patients suggested that ESA doses were lower with HDF

The downside risk is not